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BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale

BCR-ABL Testing: Resources to help molecular pathologists standardize on the international scale for BCR-ABL quantitative measurements and BCR-ABL Testing

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BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale | whereareyouontheis.net Reviews
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BCR-ABL Testing: Resources to help molecular pathologists standardize on the international scale for BCR-ABL quantitative measurements and BCR-ABL Testing
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BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale | whereareyouontheis.net Reviews

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BCR-ABL Testing: Resources to help molecular pathologists standardize on the international scale for BCR-ABL quantitative measurements and BCR-ABL Testing

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BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale

http://www.whereareyouontheis.net//Default.aspx

INTERNATIONAL SCALE COMMON QUESTIONS. What is a BCR-ABL1 monitoring test? How are BCR-ABL1 monitoring results reported? What is the International Scale for standardization of quantitative BCR-ABL1 result reporting? What is the importance of the IS? How do I standardize my lab to the IS? Can any lab become standardized to the IS? Once my lab has become standardized to the IS, how do I maintain a valid IS conversion factor? Is there an IS reference material available? Can e1a2 be reported on the IS? The In...

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BCR-ABL Tyrosine Kinase, BCR-ABL Tyrosine Kinase Inhibitors

http://www.whereareyouontheis.net//BCR-ABLTherapeutics.aspx

BCR-ABL1 TYROSINE KINASE INHIBITORS. This website is sponsored by Asuragen ASURAGEN HOME. 877777.1874 bcrablisbd@asuragen.com. This website is not funded by or hosted for any advertising source.

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BCR-ABL Test, BCR-ABL Testing, BCR-ABL International Scale

http://www.whereareyouontheis.net/BCR-ABLPublications.aspx

Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program. Leukemia 2003; 17:2318-2357. N Engl J Med 2003; 349: 1423-1432. Clin Cancer Res 2005; 11: 3425-3432. Blood 2006; 108: 28-37. Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F et al&#4...

4

BCR-ABL Test, BCR-ABL Testing, BCR-ABL International Scale

http://www.whereareyouontheis.net//BCR-ABLPublications.aspx

Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program. Leukemia 2003; 17:2318-2357. N Engl J Med 2003; 349: 1423-1432. Clin Cancer Res 2005; 11: 3425-3432. Blood 2006; 108: 28-37. Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F et al&#4...

5

BCR-ABL Testing, BCR-ABL Testing and the International Scale, BCR-ABL Test

http://www.whereareyouontheis.net//BCR-ABLTesting.aspx

The IS is anchored to the baseline BCR-ABL1 expression level from the International Randomized Study of Interferon vs. STI571 (IRIS) trial (100% IS) with a major molecular response (MMR) corresponding to 0.1% IS. (Hughes et al., N Engl J Med 2003). The IRIS and follow up studies have demonstrated that achieving MMR, or a 3-log reduction in BCR-ABL1 expression from the standardized baseline level, is a key clinical outcome. This website is sponsored by Asuragen ASURAGEN HOME.

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