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Drug design, discovery and selection U1177, Deprezlab

U1177 (formerly U761), directed by Pr. Benoit Deprez, is dedicated to drug design, discovery and selection. The Lab's mission is to design and study compounds that modulates selected molecular targets in a desired way to treat infectious and metabolic diseases. Our projects engage researchers across physical, chemical and biological sciences to trade ideas and knowledge and sincerely endeavor to v ...

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Drug design, discovery and selection U1177, Deprezlab | deprezlab.fr Reviews
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U1177 (formerly U761), directed by Pr. Benoit Deprez, is dedicated to drug design, discovery and selection. The Lab's mission is to design and study compounds that modulates selected molecular targets in a desired way to treat infectious and metabolic diseases. Our projects engage researchers across physical, chemical and biological sciences to trade ideas and knowledge and sincerely endeavor to v ...
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Drug design, discovery and selection U1177, Deprezlab | deprezlab.fr Reviews

https://deprezlab.fr

U1177 (formerly U761), directed by Pr. Benoit Deprez, is dedicated to drug design, discovery and selection. The Lab's mission is to design and study compounds that modulates selected molecular targets in a desired way to treat infectious and metabolic diseases. Our projects engage researchers across physical, chemical and biological sciences to trade ideas and knowledge and sincerely endeavor to v ...

INTERNAL PAGES

deprezlab.fr deprezlab.fr
1

PfAM1 inhibitors

https://www.deprezlab.fr/web/pfam1%20inhibitors/1011306087/list1187970176/f1.html

Insulin Degrading Enzyme modulators. Contracts, industrial partners. Rebecca Deprez MRSC PhD PharmD - Professor. Former team members :. Marion Flipo – Assistant Pr. Virginie Leroux – Technician. Using chemical Biology, validate PfAM1 as a drug target and develop new strategies for the treatment of malaria. Characterized the aminopeptidase M1 (. M1AAP) that shows a strict aminopeptidase activity at pH 7.4 and a broad substrate spectrum. AM1 degrades oligopeptides resulting from haemoglobin digestion eithe...

2

Laboratory INSERM U761

https://www.deprezlab.fr/web/laboratory%20inserm%20u761/1011306087/list1187970164/f1.html

Insulin Degrading Enzyme modulators. Contracts, industrial partners. Institut Pasteur de Lille.

3

ADME

https://www.deprezlab.fr/web/adme/1011306087/list1187970116/f1.html

Insulin Degrading Enzyme modulators. Contracts, industrial partners. Early-formulation, -ADME and -pharmacokinetics. Team Leader: Florence Leroux PhD. Catherine Piveteau- Assistant engineer. Alexandre Biela - technician. Evaluation of ADME parameters early in the discovery process is widely used during target validation, hit-discovery, hit-to-lead optimisation stages. We have developed a platform that allows to evaluate these parameters rapidly. Institut Pasteur de Lille.

4

MABA inhibitors

https://www.deprezlab.fr/web/maba%20inhibitors/1011306087/list1187970178/f1.html

Insulin Degrading Enzyme modulators. Contracts, industrial partners. Marion Flipo PhD - Assistant. Pr Nicolas Willand PhD - Professor. Hughes Prevet - PhD student. Develop a fragment-based approach to discover drug-like inhibitors of MabA as a new strategy to treat tuberculosis. Tuberculosis causes every year 1.4 million deaths worldwide therefore molecules that are active against unexploited targets are obviously needed. Mycolic acids are very long-chain fatty acids (C60–C90). The front-line antibiotic ...

5

Insulin Degrading Enzyme modulators

https://www.deprezlab.fr/web/insulin%20degrading%20enzyme%20modulators/1011306087/list1187970172/f1.html

Insulin Degrading Enzyme modulators. Contracts, industrial partners. Insulin Degrading Enzyme modulators. Insulin Degrading Enzyme modulators. Pr Rebecca Deprez-Poulain PhD PharmD MRSC. Damien Bosc - Ass. Prof. Paul Hermant - PhD student. Jouda Jakhlal - PostDoc. Julie Dumont - Ass Eng. Florence Leroux PhD -PharmD. Gonzague Berte - PhD student. Damien Bosc PhD - Post-doc. Tristan Verdelet PhD -Post-doc. Jamal Elbakali PhD -Post-doc. Cyril Ronco PhD - Post-Doc. Xavier Marechal PhD - Post-doc.

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Deprez'lab Drugs & Molecules for Living Systems

http://www.insulysin.org/web/deprez_lab%20biostructures%20and%20drug%20discovery%20_inserm%20u761_/1011306087/list1187970070/f1.html

See our new publication in Nature Comm that shows for the first time the effect of a catalytic site inhibitor of IDE in vivo:. Deprez-Poulain, R., et al Nature Comm., 2015. Deprez'lab Drugs and Molecules for Living Systems. Our laboratory's mission is to design and study compounds that modulates selected molecular targets in a desired way to treat infectious. For more information visit our website. 2016 Design : Antalys.

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Drug design, discovery and selection U1177, Deprezlab

Insulin Degrading Enzyme modulators. Contracts, industrial partners. Reversion of antibiotic resistance by SMARt-420. Read U1177 and U1019 paper in Science:. Blondiaux, N., et al. Reversion of antibiotic resistance in M. tuberculosis by SMARt-420. Science,2017, 355(6330): 1206-1211. doi:10.1126/science.aag1006. Biological version of malware reverses antibiotic resistance in TB. Nat Chem. Biol. Nat Rev. Drug Disc. Reviving a Drug for Tuberculosis? Reversing resistance to a tuberculosis antibiotic. Modulat...

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Check what we can do for your business. Building High Function Leadership Teams. Developing High Performing Individual Leaders. Creating Positive Employee First Cultures. Take Your Team To The Next Level. Develop Leadership and Management Skills. We provide the tools and methods to. Implement a consistent system that everyone. In the organization can understand and support. Want to know more? Fill it to download Pdf.