quintaradiscovery.com

Quintara Discovery | Quintara Discovery, a discovery & development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening.

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Your partner in drug discovery and development. State-of-the-art instrumentation, meticulous method development and analysis with precision and accuracy. 170 Harbor Way, South San Francisco, CA 94080.

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Quintara Discovery | Quintara Discovery, a discovery & development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. | quintaradiscovery.com Reviews

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Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Your partner in drug discovery and development. State-of-the-art instrumentation, meticulous method development and analysis with precision and accuracy. 170 Harbor Way, South San Francisco, CA 94080.

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1 quintara discovery

2 about us

3 mission

4 advantages

5 team

6 capabilities

7 adme

8 metabolic stability

9 microsomal stability

10 s9 stability

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Quintara Discovery | Quintara Discovery, a discovery & development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. | quintaradiscovery.com Reviews

https://quintaradiscovery.com

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Your partner in drug discovery and development. State-of-the-art instrumentation, meticulous method development and analysis with precision and accuracy. 170 Harbor Way, South San Francisco, CA 94080.

INTERNAL PAGES

quintaradiscovery.com

1

TDI – IC50 Shift – Quintara Discovery

http://quintaradiscovery.com/adme/cyp450-interactions/time-dependent-inhibition-ic50-shift

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Time-Dependent Inhibition IC50 Shift: Standard Assay Conditions (Customizable). CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 (other isoforms are available). Pooled human liver microsomes. 0 and 30 min /- NADPH.

2

TDI/MBI – kinact/KI – Quintara Discovery

http://quintaradiscovery.com/adme/cyp450-interactions/time-dependent-inhibition-kinactki

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Time-Dependent Inhibition kinact/Ki: Standard Assay Conditions (Customizable). CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 (other isoforms are available). Pooled human liver microsomes. KI, kinact, detailed Report.

3

CYP450 Ki Determinations – Quintara Discovery

http://quintaradiscovery.com/adme/cyp450-interactions/cyp450-ki-determinations

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Detailed enzyme kinetic measurement at various inhibitor and substrate concentrations will yield the Ki value and the mode of inhibition (competitive, non-competitive, uncompetitive and mixed). Pooled human liver microsomes.

4

CYP450 Induction – Quintara Discovery

http://quintaradiscovery.com/adme/cyp450-interactions/cyp450-induction

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Because CYP induction is a metabolic liability in drug therapy, it is highly desirable to develop new drug candidates that are not potent CYP inducer to avoid the potential of CYP induction-mediated drug interactions.

5

Caco-2 Permeability – Quintara Discovery

http://quintaradiscovery.com/adme/permeability-transporters/caco-2-permeability

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. The Caco-2 system has become the standard format to relate drug permeability to oral drug absorption. The Caco-2 cell model exhibits morphological as well as functional similarities to human intestinal enterocytes. HBSS, pH 7&#4...

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plab.co

Our Team - Perlstein Lab

http://www.plab.co/team

PLab has built an automated drug discovery platform for rare diseases. Ethan Oren Perlstein, PhD. Nina DiPrimio, PhD. Director of Outreach and External Collaborations. An O’Reilly media publication. Tom Hartl, PhD. Director of High-Throughput Screening. Sangeetha Iyer, PhD. Director of Business Development. Alec is a recent graduate from the George Washington University where he earned a B.S in Biology. Originally focused on emergency medicine, Alec is now taking a turn in the field of research, ...I con...

konradimolecular.com

Konradi Molecular: Partners

http://www.konradimolecular.com/partners.html

As needed to advance projects, KM introduces clients to contract research organizations and other consultants with different capabilities. KM does not receive payments from any service providers. Integrated R and D Services Including CMC / GMP. Integrated Drug Discovery and Development Services. High Value Chemical Synthesis. Integrated Drug Discovery Services. In Vitro Assays, ADME, and PK Bioanalysis. 18F Fluorination for PET. Integrated Drug Discovery Services. Organic Synthesis and Medicinal Chemistry.

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Quintara Discovery | Quintara Discovery, a discovery & development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening.

Quintara Discovery, a discovery and development specialist based in the San Francisco Bay Area, provides high-quality in vitro ADME profiling, bioanalysis services, and dedicated assay development and compound screening. Permeability & Transporters. Chemical Stability in Buffers. Your partner in drug discovery and development. State-of-the-art instrumentation, meticulous method development and analysis with precision and accuracy. 170 Harbor Way, South San Francisco, CA 94080.

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