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German Israeli Project: Alternative pre-mRNA splicing of ion channels

This collaboration investigates how the read-out of genetic information is modulated by alternative splicing through primate-specific genetic elements and cellular activity. Bioinformatics, genetics, molecular biology and electrophysiology experts will jointly explore the reciprocal relationship between alternative splicing and cellular activity as it is influenced by mutations and mobile genetic elements. By alternative splicing, mammalian organisms generate a complex and highly plastic expression pattern

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German Israeli Project: Alternative pre-mRNA splicing of ion channels | dip.molmed.eu Reviews
<META>
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This collaboration investigates how the read-out of genetic information is modulated by alternative splicing through primate-specific genetic elements and cellular activity. Bioinformatics, genetics, molecular biology and electrophysiology experts will jointly explore the reciprocal relationship between alternative splicing and cellular activity as it is influenced by mutations and mobile genetic elements. By alternative splicing, mammalian organisms generate a complex and highly plastic expression pattern
<META>
KEYWORDS
1 german israeli project
2 alternative pre mrna splicing
3 of ion channels
4 executive summary
5 additional information
6 graphic representation
7 participants
8 gil ast
9 cord michael becker
10 batsheva kerem
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german israeli project,alternative pre mrna splicing,of ion channels,executive summary,additional information,graphic representation,participants,gil ast,cord michael becker,batsheva kerem,arthur konnerth,hermona soreq,stefan stamm,work packages,human
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German Israeli Project: Alternative pre-mRNA splicing of ion channels | dip.molmed.eu Reviews

https://dip.molmed.eu

This collaboration investigates how the read-out of genetic information is modulated by alternative splicing through primate-specific genetic elements and cellular activity. Bioinformatics, genetics, molecular biology and electrophysiology experts will jointly explore the reciprocal relationship between alternative splicing and cellular activity as it is influenced by mutations and mobile genetic elements. By alternative splicing, mammalian organisms generate a complex and highly plastic expression pattern

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German Israeli Project: Alternative pre-mRNA splicing of ion channels

http://dip.molmed.eu/exsum.htm

Indeed, aberrant alternative splicing is increasingly recognized as a cause and consequence of human disease, including neurological disorders and cystic fibrosis. Novel therapeutic approaches demonstrated that missplicing events can be reversed, but animal models to test further treatments are still lacking. The project will lead to. Improved understanding of how the genetic information is used to generate and modify higher human cognitive functions,.

2

WP2: Allelic variations that govern alternative splicing of the CFTR ion channel

http://dip.molmed.eu/workpack/WP2.htm

WP2: Allelic variations that govern alternative splicing of the CFTR ion channel. WP2: Allelic variations that govern alternative splicing of the CFTR ion channel. Ayelet Rahat, Mira Korner, Malka Nissim-Rafinia, Liat Shushi, Michal Shuker, Efrat Ozeri, Asaf Bester,. Electro- physiology. Our specific aims are:. Generating a knock-in mouse model carrying the mutation on different strain backgrounds. Testing the effect of compounds that. Description of the work:. Increases the amount of correctly spliced C...

3

WP3: Regulation of splice site selection by Ca++ concentration-dependent phosphorylation of splicing factors

http://dip.molmed.eu/workpack/WP3.htm

WP3: Regulation of splice site selection by Ca. Concentration-dependent phosphorylation of splicing factors. WP3: Regulation of splice site selection by Ca. Concentration-dependent phosphorylation of splicing factors. Ilona Rafalska, Zhayi Zhang, Bettina Heinrich, Shivendra Kishore, Natalya Benderskaya, Tatyana Novoyatleva, Yesheng Tang,. Target RNAs, to determine. The influence of trkB-T1-activity dependent Ca. Fluctuations on alternative splicing. Description of the work:. CLIP) and compared with the C...

4

WP4: Mobile genetic elements causing hypertonic motor disorders through missplicing of ion channels

http://dip.molmed.eu/workpack/WP4.htm

WP4: Mobile genetic elements causing hypertonic motor disorders through missplicing of ion channels. WP4: Mobile genetic elements causing hypertonic motor disorders through missplicing of ion channels. Kristina Becker, Andreas Humeny, Marlen Braune, Julia Brill, Silke Seeber,. We use the -subunit of the chloride channel glycine receptor (GlyR) to identify splicing factors as genetic modulators of neuronal missplicing caused by mobile genetic elements. Our aims are. Description of the work:. Gene causes ...

5

Dr. Gil Ast, Ph.D.

http://dip.molmed.eu/part/ast.htm

Dr Gil Ast, Ph.D. Tel Aviv University Medical School. Senior Lecturer in Molecular Medicine. And the Human Genetics. Department of Human Genetics and Molecular Medicine. Tel Aviv 69978, Israel. Tel: ( 972-3) 640 6893. Fax: ( 972-3) 640 9900. Gilast@post.tau.ac.il.

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Institut für Biochemie. Der Medizinischen Fakultät. Institut für Biochemie. Folien, Skripte, Zeitpläne. Zu unseren Vorlesungen informieren Sie sich bitte bei Studon:. Http:/ www.studon.uni-erlangen.de/. Folien, Skripte, Zeitpläne. Design und Layout Institut für Biochemie der Universität Erlangen Nürnberg - Impressum.

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Institut für Biochemie - Friedrich-Alexander-Universität Erlangen-Nürnberg

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Institut für Biochemie. Der Medizinischen Fakultät. Institut für Biochemie. AG Bosserhoff (Lehrstuhl 1). AG Wegner (Lehrstuhl 2). Lehrstuhl für Biochemie und Molekulare Medizin. Leitung: Prof. Dr. Anja-Katrin Bosserhoff. Lehrstuhl für Biochemie und Pathobiochemie. Leitung: Prof. Dr. Michael Wegner. Leitung: Prof. Dr. Ewald Hannappel. Curriculum vitae E. Hannappel. Lecture on "Chemistry of Thymosins". Professur für Molekulare Medizin mit dem Schwerpunkt Molekulare Bildgebung. Leitung: Dr. Wei Xiang.

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Institut für Biochemie. Der Medizinischen Fakultät. Institut für Biochemie. Institut für Biochemie. Verantwortlich für Text und Inhalt:. Prof Dr. rer. nat. M. Wegner. Die Verantwortlichkeit der Texte und Abbildungen unter der Sektion Forschung unterliegt den jeweiligen Arbeitsgruppen. Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst. Die Umsatzsteuer-Identifikationsnummer gemäß 27a Umsatzsteuergesetz lautet DE 132507686. Hinweise zu externen Links:.

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German Israeli Project: Alternative pre-mRNA splicing of ion channels

Generation of new alternative exons through mobile genetic elements. Allelic variations that govern alternative splicing of the CFTR ion channel. Regulation of splice site selection by Ca. Concentration-dependent phosphorylation of splicing factors. Mobile genetic elements causing hypertonic motor disorders through missplicing of ion channels. Control of calcium-dependent gene expression through receptor tyrosine kinase TrkB isoform. Kishore, S., and Stamm, S. (2006). 230-232. (Epub 2005 Dec 15.). Prof D...

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