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BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale

BCR-ABL Testing: Resources to help molecular pathologists standardize on the international scale for BCR-ABL quantitative measurements and BCR-ABL Testing

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BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale | bcris.org Reviews
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BCR-ABL Testing: Resources to help molecular pathologists standardize on the international scale for BCR-ABL quantitative measurements and BCR-ABL Testing
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BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale | bcris.org Reviews

https://bcris.org

BCR-ABL Testing: Resources to help molecular pathologists standardize on the international scale for BCR-ABL quantitative measurements and BCR-ABL Testing

INTERNAL PAGES

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1

BCR-ABL Tyrosine Kinase, BCR-ABL Tyrosine Kinase Inhibitors

http://www.bcris.org//BCR-ABLTherapeutics.aspx

BCR-ABL1 TYROSINE KINASE INHIBITORS. This website is sponsored by Asuragen ASURAGEN HOME. 877777.1874 bcrablisbd@asuragen.com. This website is not funded by or hosted for any advertising source.

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BCR-ABL Testing, BCR-ABL Testing and the International Scale, BCR-ABL Test

http://www.bcris.org//BCR-ABLTesting.aspx

The IS is anchored to the baseline BCR-ABL1 expression level from the International Randomized Study of Interferon vs. STI571 (IRIS) trial (100% IS) with a major molecular response (MMR) corresponding to 0.1% IS. (Hughes et al., N Engl J Med 2003). The IRIS and follow up studies have demonstrated that achieving MMR, or a 3-log reduction in BCR-ABL1 expression from the standardized baseline level, is a key clinical outcome. This website is sponsored by Asuragen ASURAGEN HOME.

3

BCR-ABL Testing and International Scale Webinars, BCR-ABL Tests

http://www.bcris.org//BCR-ABLWebinar.aspx

Monitoring CML Patients by RT PCR on the International Scale. Presented by Nick Cross, MA, PhD, FRCPath Professor of Human Genetics at Wessex Regional Genetics Laboratory, U.K. Click here to view this webinar recorded September 26th, 2011. If you are having trouble viewing this video install the gotomeeting video codec found here. Click here to view Dr. Cross's PowerPoint slides. Comprehensive coverage of why, when and how IS standardisation was established. Review the definitions of response. BCR-ABL1 Q...

4

BCR-ABL Testing, BCR-ABL Test, BCR-ABL International Scale

http://www.bcris.org//Default.aspx

INTERNATIONAL SCALE COMMON QUESTIONS. What is a BCR-ABL1 monitoring test? How are BCR-ABL1 monitoring results reported? What is the International Scale for standardization of quantitative BCR-ABL1 result reporting? What is the importance of the IS? How do I standardize my lab to the IS? Can any lab become standardized to the IS? Once my lab has become standardized to the IS, how do I maintain a valid IS conversion factor? Is there an IS reference material available? Can e1a2 be reported on the IS? The In...

5

BCR-ABL Test, BCR-ABL Testing, BCR-ABL International Scale

http://www.bcris.org//BCR-ABLPublications.aspx

Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N et al. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program. Leukemia 2003; 17:2318-2357. N Engl J Med 2003; 349: 1423-1432. Clin Cancer Res 2005; 11: 3425-3432. Blood 2006; 108: 28-37. Baccarani M, Saglio G, Goldman J, Hochhaus A, Simonsson B, Appelbaum F et al&#4...

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INTERNATIONAL SCALE COMMON QUESTIONS. What is a BCR-ABL1 monitoring test? How are BCR-ABL1 monitoring results reported? What is the International Scale for standardization of quantitative BCR-ABL1 result reporting? What is the importance of the IS? How do I standardize my lab to the IS? Can any lab become standardized to the IS? Once my lab has become standardized to the IS, how do I maintain a valid IS conversion factor? Is there an IS reference material available? Can e1a2 be reported on the IS? The In...

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